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Genex is a
new concept in synthetic, fully resorbable bone graft,
conferred with a property unique to bone void fillers,
Zeta Potential Control (ZPC™) |
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Genex - Injectable Bone Graft with ZPCTM
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geneX is a new concept in synthetic, fully resorbable bone
graft, conferred with a property unique to bone void fillers,
Zeta Potential Control (ZPC™).
geneX is also engineered with SmartPores, which produce a
developing macroporosity, drawing in cells and nutrients as
the graft is absorbed. Applied as an injectable paste, geneX
can be contoured to the surgical site, and sets in-situ at
body temperature to an exceptional compressive strength.
ZETA POTENTIAL CONTROL (ZPC™)
The importance of a material’s surface properties in achieving
optimal biological activity and bone formation†‡ has been well
documented. geneX’s proprietary process of Zeta Potential
Control, carefully controls the surface chemistry of the
material.
This has been shown to harness a number of key proteins that
function as regulatory molecules for bone regeneration,
including:
• CBFA1 - An essential transcription factor for Osteoblast
differentiation
• Collagen Type 1 - Serves as an anchor for the attachment of
bone forming cells
Harnessing these proteins enhances bone cell activity,
resulting in accelerated bone growth.
SMARTPORES
geneX possesses two calcium phases which resorb within the
defect site at different rates. One calcium phase acts as a
nanoporous barrier to soft tissue infiltration, whilst
providing soluble calcium ions for bone regeneration.
It's early stage resorption creates a macroporous matrix
allowing key cell and nutrient infiltration, whilst exposing
the other calcium phase.
This second calcium phase resorbs over several months, whilst
hosting trabecular bone formation. |
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REFERENCES
† Masataka Ohgaki et al, Manipulation of cell proliferation by
electrically polarized hydroxyapatite. Key Engineering
materials Vols. 218-22. Pages 249-252. (2002)
‡ Heipp PS et al, Osteoblast attachment to titanium surfaces
as a function of surface charge, Dept. of Orthopedic Surgery
Research, Thomas Jefferson University, Philadelphia, PA.
ORDER CODES
5cc 900-005
10cc 900-010
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