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Genex is a
new concept in synthetic, fully resorbable bone graft,
conferred with a property unique to bone void fillers,
Zeta Potential Control (ZPC™) |
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geneX Putty - Preloaded Injectable bone
graft with ZPC™
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geneX® putty is a unique synthetic bone graft material, which
possesses a consistent controlled negative surface charge (ZPC™).
This initiates reproducible cell activity, driving
endochondral ossification as the putty is fully resorbed and
replaced by bone.
geneX® putty has been designed with an optimised composition
of β-Tri Calcium Phosphate and an ultra pure Calcium Sulphate
component, produced by a patented manufacturing process.
geneX® is the only bone graft material to show bone growth in
the clinically relevant ’Boden’ Model, without the addition of
BMPs, Autograft, marrow or growth factors.
KEY ADVANTAGES
• Negative surface charge for rapid bone formation
• Fully resorbable and replaced by bone
• Superior handling capabilities and conforms to the surgical
site
• Resists migration at operative site
• Fully synthetic – eliminating the risk of disease
transmission
ZPC™ Zeta Potential Control
Biocomposites has developed a unique process, ZPC™ making
geneX the only bone graft material with a controlled,
reproducible negative surface charge. This process controls
the graft surface properties, initiating reproducible cell
activity and accelerating bone formation.1,2
Key proteins are harnessed at the graft surface, directing
bone cell adhesion and proliferation for rapid osteogenesis
and bone formation.
Engineered to Drive Bone Healing though
three key stages |
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STAGE 1 |
Negative Surface charge harnesses key
proteins which enhances bone cell activity and attachment. |
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Surface of positively charged calcium
phosphate - limited cell attachment
Positive surface charge, In-Vitro
osteoblast culture,
3 days, (Toluidine Blue stain) |
Surface of negatively charged geneX® -
prolific cell attachment and proliferation
ZPC™ Negative Surface Charge,
In-vitro osteoblast culture, 3 days, (Toluidine Blue
stain) |
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STAGE 2 |
Sulphate phase, as it resorbs, stimulates the formation of
the cartilage intermediate phase – Endochondral
Ossification. |
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S
In-vivo, 4 weeks post
implantation. (H&E stain, Magnification x10) |
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STAGE 3 |
Negative surface charge facilitates the transition from
cartilage to new bone. geneX naturally resorbed through
bone remodelling process. Calcium ions aid mineralisation
of new bone. |
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In-vivo, 8 weeks post
implantation. NB - New Bone,
GP - geneX® putty
(H&E stain, Magnification x10) |
Residual geneX®
putty is fully incorporated into new bone formation, to be
naturally resorbed through remodelling processes. |
REFERENCES
1. Ohgaki M, et al. "Manipulation
of cell proliferation by electrically polarized hydroxyapatite.",
Key Engineering Materials (2002), Vols 218-220, pp 249-252
2. Teng N C, et al. "A new approach to enhancement of bone
formation by electrically polarized hydroxyapatite." , J Dent.
Res (2001), Oct, Vol 80, No 10, pp 1925-1929.
ORDER CODES
2.5cc 920-002
5cc 920-005
10cc 920-010
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